Johnny Depp is "The Tourist"

This US remake of French thriller "Anthony Zimmer" has been playing a game of muscial chairs with it's cast and director choices, but finally it seems the studio have hit on a pairing that will have them drooling at the mouth and seeing $ signs dancing across their eyes.

Johnny Depp is the latest to sign on for the male lead (once set for Tom Cruise and then Sam Worthington) and he will star oppostie the already cast Angelina Jolie (Who replaced Charlize Theron).

Directing duties have shifted a number of times as well but it seems they have finally settled on the rather awesome choice of Alfonso "Children of Men" Cuaron!

With the sexy, megastar box office drawing lead combo (who also happen to be fine actors) and a gifted director like Cuaron, this is suddenly shaping up to be one to keep tabs on.

The Hollywoodreporter has the details:

Spyglass Entertainment's thriller remake "The Tourist" has run into another set of hiccoughs, with major players shifting around like luggage on a conveyor. Male lead Sam Worthington has fallen off, and Johnny Depp is in negotiations to replace him.

Additionally, after flirting with the project director Florian Henckel von Donnersmarck has moved on, and Alfonso Cuaron is in early talks to step in. Bharat Nalluri was once attached to direct with Tom Cruise in the lead role.

Angelina Jolie -- herself a recent replacement for Charlize Theron, who was long attached to the project -- remains in the lead female role.

The revamp of the 2005 French spy thriller "Anthony Zimmer" involves a female Interpol agent who ropes an everyman American tourist visiting France into being bait in the hunt for a wanted criminal who's also her former lover.

Graham King's GK Films is financing and distributing through its new output deal with Sony.

The UTA-repped Depp has several films in the can -- "Alice in Wonderland," "The Rum Diary" -- but has been waiting to get his next project moving. The fourth "Pirates of the Caribbean" at Disney had been a strong possibility.